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Most PCs are built the same way around.
UpdateI've been running the PC like this for a few months now and it is doing it's job nicely. The only issue I have is that since moving the PC onto the desk, I have noticed the noise of the fans more than before. It's pretty quiet, but not entirely silent. The CPU fan was fairly quiet, I tried various fan profiles, but the real issue turned out to be the power supply fan.
2022 Update: This PC is still running pretty much as shown here. All that has changed is I added two extra sticks of RAM and an NVMe drive in a PCIe slot.